Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration.

نویسندگان

  • Jian Li
  • Robert W Milne
  • Roger L Nation
  • John D Turnidge
  • Timothy C Smeaton
  • Kingsley Coulthard
چکیده

The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 5  شماره 

صفحات  -

تاریخ انتشار 2003